Dr. Holt attended Columbia University's College of Physicians & Surgeons, and subsequently completed his residency and Chief Residency at Yale School of Medicine's Primary Care Internal Medicine Residency Program before joining the faculty. He has served as the Associate Program Director of Yale's Primary Care Program since 2010. His areas of interest include addiction medicine, medical education, and the art and science of physical diagnosis. He is board-certified in both Internal Medicine and Addiction Medicine. 

Current clinical activities include ambulatory clinic precepting, co-directing Yale's Addiction Recovery Clinic, and general medicine ward attending several months per year. He is the director of Musculoskeletal Education and Addiction Medicine Education within the Primary Care training program, and codirects the Clinician Educator Distinction Track within the Department of Medicine. He has won numerous teaching awards at Yale and nationally, including the Faculty Teacher of the Year Award (Yale Primary Care Residency, 2009 and 2017), the Leonard Tow Humanism in Medicine Award (Yale School of Medicine, 2014), and the New Investigator/Educator Award (Association for Medical Education and Research in Substance Abuse,2016) and gives recurring lectures on physical diagnosis, medical education, and addiction medicine topics both at Yale and nationally. 

Dr. Holt has authored numerous articles, reviews, and book chapters on addiction medicine topics and is a premier author for Yale's Office-based Medicine Curriculum, used by over 200 residency programs nationally.

Outside of the hospital, Dr. Holt is an avid guitarist and naturalist who genuinely enjoys the art and science of tree identification. He lives in Connecticut with his wife and their two daughters (9 and 10 years old) that entertain him nightly.