Dr. Markoff was an undergraduate at the University of California, Berkeley where he received an AB (with distinction) in Biology. He received his MD from the University of California, San Francisco and went on to residency and chief residency in Internal Medicine at the University of California, Davis. After his chief year, Dr. Markoff helped start the hospitalist group at the UC Davis Medical Center.
He went to the Mount Sinai Medical Center in 2002 and served as the Associate Chief, Division of Hospital Medicine and the Associate Program Director for Quality, Internal Medicine Residency program. He is an Associate Professor of Medicine at the Icahn School of Medicine at Mount Sinai. In 2016 Dr. Markoff became the Chief, Division of Hospital Medicine at Mount Sinai St. Luke's Hospital.