Dr. Lee graduated from Mount Sinai Medical School and trained at Columbia Presbyterian Medical Center for internship and residency. After serving as a Chief Medical Resident, he joined the Section of Hospital Medicine in the Department of Medicine at Columbia University. Since 2002, he has served as an Associate Program Director for the Internal Medicine Residency Program.

Since 2003, he has been the Medical Director of the Hospitalist Program. Since 2013, he has been the Medical Director for International Services at New York Presbyterian Hospital/CUMC. He has been the Head Team Internist for the New York Yankees since 2003 and for the new MLS soccer team, New York City Football Club, since 2015.